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Resveratrol - The Miracle Nutrient for Cancer,
Cholesterol and Longevity

by Mike Adams,†

1bntarw2604†Join Now, just your first name and email address is all it takes!

You've all heard the good news about resveratrol, commonly known as the "red wine nutrient."blueberry1 There's more to resveratrol than red wine, though, and it's helpful for far more than just preventing heart disease. It's also phenomenal for maintaining a healthy cholesterol balance and even supporting increased longevity.

grape1As you'll see below in quotes from health experts about resveratrol, this "miracle" nutrient is also useful for preventing many types of cancer. As you read these quotes, pay special attention to any mention of phytoalexins, as this is a class of plant-based nutrients that you'll be hearing about much more in the future (as nutritional healing becomes more widely known).

If you want to acquire some resveratrol, there are lots of natural sources such as red wine or grape leaves (the leaves actually contain far more than the grapes themselves).

The Chinese medicine herb hu zhang is also loaded with resveratrol.


Authors' Quotes on Resveratrol

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Resveratrol is a naturally occurring phytoalexin produced by some higher plants in response to injury or fungal infection. Phytoalexins are chemical substances produced by plants as a defense against infection by pathogenic microorganisms, such as fungi. Alexin is from the Greek, meaning to ward off or to protect. Resveratrol may also have alexin-like activity for humans.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik


Doctors Signorelli and Ghidoni single out resveratrol, a red wine molecule, for its unique ability to favorably control hundreds of genes at one time. Another biologist, referring to resveratrol's ability to switch hundreds of genes, says resveratrol exerts "a whiff that induces a biologically specific tsunami." Resveratrol's ability to influence many genes was demonstrated in a gene array experiment involving kidney cancer cells.
- You Don't Have to be Afraid of Cancer Anymore by Bill Sardi


Found in many plants as a phytoalexin, resveratrol is abundant in the skins of red grapes (Vitis vinifera). It has been suggested that resveratrol underlies the phenomenon known as the "French paradox." Wine is the most notable dietary source of this compound; a fluid ounce of red wine contains an average of 160 pg of resveratrol.
- Medical Herbalism: The Science Principles and Practices Of Herbal Medicine by David Hoffman, FNIMH, AHG


Grape juice contains resveratrol, as does cranberry juice, but at levels that are ten times less than those in red. Resveratrol content in different food and beverages: (uG 100 G), OyG/125 ML) Grapes 1,500, Red wine 625, Peanuts 150, White wine 38, Peanut butter 50, Grape juice 65, Blueberries 3, Cranberry juice 65, Raisins 0.01; resveratrol concentration in red wine varies greatly from one grape variety to another and from one region to another, with values ranging from 1 to 13 mg/l.
- Foods that Fight Cancer by Richard Beliveau, Ph.D. and Denis Gingras, Ph.D.


When incubated with hepatoma cells, resveratrol induced Phase II detoxifying enzymes that detoxified and inhibited the proliferation of these cells. Resveratrol also inhibited the development of preneoplastic lesions when mice were exposed to tumor initiators and promoters. Grape skins, leaves, juice and red wine are all good sources of resveratrol.
- Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment by Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine


A series of laboratory experiments suggests that resveratrol inhibits the development of cancer in animals and prevents the progression of cancer. However, human research is still needed in this area. In another set of animal studies, resveratrol was shown to inhibit both the acute and chronic phases of inflammation.
- The Natural Pharmacy: Complete Home Reference to Natural Medicine by Schuyler W. Lininger, Jr. DC


The active ingredient of the grape extracts is a potent flavonoid called resveratrol. Italian researchers discovered something even more profound regarding the chemistry of resveratrol. They determined that this unique chemical revitalizes nerve cells. In fact, resveratrol induced portions of the nerves to regenerate, in other words, the nerves started growing again, a feat formerly deemed impossible. A reasonable conclusion is that resveratrol is a major protector of the genes, in other words, it prevents chromosome damage.
- Dr. Cass Ingram's Lifesaving Cures by Dr. Cass Ingram


A partial estrogen receptor agonist itself, resveratrol is believed by some researchers to be an estrogen-receptor antagonist in the presence of estrogen, resulting in breast cancer inhibition. Finally, resveratrol has recently shown activity against herpes simplex vims types 1 and 2 in a dose-dependent manner. It appears to disrupt a critical early event in the viral reproduction cycle.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik


Darakchasava, an ayurvedic herbal remedy, has as its principal ingredient Vitis vinifera L, and therefore, contains resveratrol. It is mainly used in ayurvedic medicine as a cardiotonic. Resveratrol, which is also known as trihydroxystilbene andstilbenetriol, exists in cis and raw stereoisomeric forms. Resveratrol is the parent molecule of a family of polymers called viniferins.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik


Resveratrol is an antioxidant found in many foods, but most abundantly in peanuts and red grapes. Red wine from cold climates (such as France) is a particularly good source of resveratrol. It is less concentrated in red wines from warmer climes such as California, Italy, Spain, or Portugal. Studies from the University of Illinois have shown that the number of early breast lesions and skin cancers in mice dropped dramatically when they were given high doses of resveratrol.
- AntioxidantsAgainst Cancer: How to activate your body's natural healing powers with today's most protective and immune-boosting supplements and foods by Ralph Moss, PhD


Hu zhang (Polygonum cuspidatum) is a Chinese herb actually a weed that is the world's richest source of resveratrol,the phytochemical also found in red wine that has generated a huge buzz for its disease-preventive actions in the body. A large body of research supports the role of resveratrol in resisting cancer, inflammation and heart disease. Resveratrol has been found to suppress the activation of inflammatory cytokines and COX-2, and shows special promise in preventing and slowing the progression of breast cancer. Resveratrol is also a potent antioxidant.
- AntioxidantsAgainst Cancer: How to activate your bod natural healing powers with today's most protective and immune-boosting supplements and foods by Ralph Moss, PhD


Virtually every pathway for tumor growth and propagation is blocked by resveratrol. Researchers appear to have developed a consensus that low concentrations of resveratrol cannot only counteract tumor initiation but can inhibit tumor cell survival. Resveratrol targets the very machinery inside cells that promote tumor cell survival. It appears to be able to concentrate its action on tumor cells rather than healthy cells. Resveratrol has also has the ability to induce cancer cells, but not normal cells, to die off.
- You Don't Have to be Afraid of Cancer Anymore by Bill Sardi


Another of the key components of grapes is resveratrol. Resveratrol belongs to a group of compounds called phytoalexins that plants produce in self-defense against environmental stressors, such as adverse weather or attack by insects or microorganisms. Resveratrol has been identified in more than seventy species of plants, including mulberries and peanuts, but the flesh of grapes is an especially good source. Resveratrol acts as an antioxidant and has also been shown to reduce the buildup of plaque in arteries.
- The Encyclopedia of Healing Foods by Michael Murray, N.D. and Joseph Pizzorno, N.D.


Grapes are a whole pharmacy of healthful nutrients, many of which are potentially life extending. Take resveratrol. Resveratrol is a compound found in red wine (and usually given the credit for red wine's health-promoting properties), and in the skins of grapes. Technically, if you want to know, resveratrol belongs to a class of compounds called phytoalexins, which are chemical substances produced by plants as a defense against attack by pathogenic microorganisms.
- The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why by Jonny Bowden, Ph.D., C.N.S.


This prolonged contact during fermentation produces significant levels of resveratrol in the finished red wine. (White wine also contains resveratrol, but the seeds and skins are removed early in the white wine-making process, reducing the amount of resveratrol in the final product.) Antioxidants like resveratrol are beneficial in preventing harmful elements in the body from attacking healthy cells.
- The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why by Jonny Bowden, Ph.D., C.N.S.


An 8-ounce glass of red wine provides approximately 640 mcg of resveratrol, while a handful of peanuts provides about 73 mcg of resveratrol. Resveratrol supplements (often found in combination with grape extracts or other antioxidants) are generally taken in the amount of 200-600 mcg per day. This is far less than the amount used in animal studies to prevent cancer : equivalent to more than 500 mg (500,000 mcg) per day for an average-sized human.
- The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions byAlan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D., Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D.Linnea D. Thompson, Pharm.D., N.D.


In test tube and animal studies, resveratrol decreased the "stickiness" of blood platelets and helped blood vessels remain open and flexible. A series of laboratory experiments suggested that resveratrol inhibits the development of cancer in animals and prevents the progression of cancer. In other animal studies, resveratrol was shown to be an effective anti-inflammatory agent. However, human research is still needed in all of these areas.
- The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions by Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D., Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D., Linnea D. Thompson, Pharm.D., N.D.


Red grapes produce a phytochemical called resveratrol, which protects them from ultraviolet radiation, fungus infections, and other stressors. Resveratrol activates anti-aging genes that stimulate the production of proteins that circulate in your body, throwing overboard cells that aren't pulling their weight and rejuvenating cells damaged by Advanced Glycation End-products (AGEs).
- Dr. Gundry's Diet Evolution: Turn Off the Genes That Are Killing You - And Your Waistline - And Drop the Weight for Good by Dr. Steven R. Gundry


Research highlights a number of resveratrol effects relevant to the cardiovascular system: Antioxidant, Inhibits peroxidation of low-density lipoprotein (LDL), Reduces platelet aggregation. Resveratrol has also been shown to function as a cancer chemopreventiveagent. Such agents reduce the incidence of tumorigenesis by intervening at one or more of the stages of carcinogenesis. In research, resveratrol demonstrated chemopreventive activity in assays representing three major stages of carcinogenesis: initiation, promotion, and progression.
- Medical Herbalism: The Science Principles and Practices Of Herbal Medicine by David Hoffman, FNIMH, AHG


Several plants, including grapevine, produce the stilbene-type phytoalexin resveratrol when attacked by pathogens. This compound appears to be one of the health-promoting factors of grapevine, which are associated with reduced risk of heart diseases (popularly known as "the French paradox") and long recognized by folk medicine. Clinical studies have demonstrated the beneficial effects of resveratrol, isolated from red wine, on cardiovascular disease and confirmed the involvement of resveratrol in fighting arteriosclerosis and vascular tissue diseases.
- Handbook of Medicinal Plants by Amarjit S. Basra


Anderson Cancer Center reviewed dozens of studies on resveratrol and concluded that it exhibited anticancer properties against a wide range of tumor cells, including lymphoid and myeloid cancers, multiple myeloma, cancers of the breast, prostate, stomach, colon, pancreas, and thyroid, melanoma, head and neck squamous cell carcinoma, ovarian, carcinoma, and cervical carcinoma. The researchers concluded that "resveratrol appears to exhibit therapeutic effects against cancer." Resveratrol may be one of the best antiaging substances around.
- The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why by Jonny Bowden, Ph.D., C.N.S.


Resveratrol is a compound produced by grapes in self-defense against environmental stressors, such as attack by insects or fungal infection. Organically grown grapes have been found to produce much higher amounts of resveratrol than conventionally grown grapes, which are already protected by treatment with man-made fungicides.
- The Encyclopedia of Healing Foods by Michael Murray, N.D. and Joseph Pizzorno, N.D.


This may also be why resveratrol has such powerful research showing it not only prevents cancer, but may actually be considered as a treatment. Resveratrol stops cancer in a variety of ways, from blocking estrogens and androgens to modulating genes. It has even shown a 30-71 percent ability to block bone metastasis. Resveratrol appears to moderate the body's detrimental inflammatory response to injury of the brain and spinal cord. It has also been shown to protect on many levels, including the antioxidant level, against heart and blood vessel disease.
- Spiritual Nutrition: Six Foundations for Spiritual Life and the Awakening of Kundalini by Gabriel Cousens, M.D.


At the time that book was written, Japanese researchers had just discovered an antifungal compound in grapes called resveratrol, which lowered cholesterol levels in rats and showed promise of doing the same in humans. Since then, researchers at the University of Illinois, under the direction of Dr. John Pezzuto, have uncovered new and exciting information about resveratrol. Studies have shown that resveratrol may prevent heart disease in two important ways. First, it inhibits the formation of blood clots, which can trigger both heart attack and stroke.
- Earl Mindell's Supplement Bible: A Comprehensive Guide to Hundreds of NEW Natural Products that Will Help You Live Longer, Look Better, Stay Heathier, ... and Much More! by Earl Mindell, R.Ph., Ph.D.


Red wine catechins are extracted from the skin of red wine grapes. The most active red wine catechin is resveratrol,a compound the grape plant manufactures in the skin of the fruit to deter gray mold. Although red wine catechins are found in purple grapejuice and red wine, resveratrol is most abundant in immature grapes (which are more susceptible to mold) and in grapes grown in damp climates, especially on Long Island in New York.
- Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies by Phyllis A. Balch, CNC


Pezzuto and colleagues were able to show that resveratrol was effective during all three phases of the cancer process: initiation, promotion, and progression. For example, resveratrol displayed antimutagenic and antioxidant activity, providing greater protection against DNA damage than vitamins C, E, or beta-carotene. UIC researchers showed that resveratrol restored glutathione levels, considered by some the most essential of antioxidants (Jang et al. 1999).
- Disease Prevention and Treatment by The Life Extension Editorial Staff


The second has been the discovery of a substance named resveratrol, a natural phytoalexin found in grapes, which may play a role in preventing heart attacks. Resveratrol appears also to inhibit cellular processes that are associated with tumor initiation, promotion, and progression. Most of the known vitamins and trace minerals are present in grapes. Resveratrol (which is related to another compound found in health food stores, quercetin) is found in wine at twice the level of grape juce.
- Herbs Against Cancer: History and Controversy by Ralph W. Moss PhD


Other studies, in animals and in vitro, have shown that resveratrol can inhibit the oxidation of LDL-cholesterol and, more recently, that it can reduce smooth muscle cell proliferation, believed to be one of the requisites of atherogenesis, by 70-90%, in a dose-dependent pattern. Red wine extract and resveratrol have shown equally significant cardioprotective effects in animal models of myocardial ischemic reperfusion injury. Additional evidence suggests that resveratrol also has estrogenic effects that may also provide cardiovascular protection.
- PDR for Nutritional Supplements by Sheldon Saul Hendler and David Rorvik


Other researchers are impressed with the range of activity that resveratrol appears to have against cancer, and some believe that there may be even more powerful agents to be found in fruits and vegetables. Thomas W. Kensler of the Johns Hopkins University School of Public Health said that the resveratrol discovery "provides the scientific underpinnings" for studies that have found health benefits from grapes and wine. Grapeseed extract is a commercial grape formulation that does not contain resveratrol.
- The Natural Pharmacist: Your Complete Guide to Reducing Cancer Risk by Richard Harkness


The large amount of resveratrol present in red wine is explained not only by the prolonged fermentation period of the grape (the grape juice that still contains the fruit's skins and seeds), during which the molecules are extracted from the skins and seeds, but also by the fact that the absence of oxygen in the bottle prevents the resveratrol from oxidizing. This is why raisins, also very rich in polyphenols, do not contain any resveratrol, which in their case is degraded by exposure to air and sunlight.
- Foods that Fight Cancer by Richard Beliveau, Ph.D. and Denis Gingras, Ph.D.


Although the anti-cancer potential of red wine remains to be more clearly established, there is no doubt that this anti-cancer activity is in large part due to the presence of resveratrol. In fact, of all naturally occurring molecules possessing anti-cancer activity that have recently been studied, resveratrol commands a great deal of enthusiasm.
- Foods that Fight Cancer by Richard Beliveau, Ph.D. and Denis Gingras, Ph.D.


Even more interesting from a nutritional point of view are recent results indicating that certain molecules of dietary origin, including quercetin and especially resveratrol, are very powerful sirtuin activators; it is this activation that may increase cell longevity. For example, the addition of resveratrol to a growth culture of single-celled organisms such as yeast increases cell lifespan by 80%. Generally, yeasts live for nineteen generations; adding resveratrol boosted life expectancy to a maximum of thirty-eight generations!
- Foods that Fight Cancer by Richard Beliveau, Ph.D. and Denis Gingras, Ph.D.


Grapes, as well as many berries and some nuts, contain a phytoalexin component called resveratrol that has shown cancer chemo preventive activity. Resveratrol has been found to act as an antioxidant, antimutagen, and anti-inflammatory. It has also been shown to inhibit the development of breast cancer and induce antiprogression activity in human myelocytic leukemia. The highest levels of resveratrol (up to one hundred times more than grapes) are found in grape leaves.
- Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment by Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine


It is now believed that the blood thinning resveratrol, as well as the so called flavonoids in red wine, are partial antidotes and help maintain a healthy heart. Resveratrol is a natural fungicide produced by grapes and is primarily found in their skins. Because resveratrol is produced in much higher quantities in grapes that are organically grown, organic red grapes may be a good option if you don't want to drink wine. Wine grapes are crushed with the seeds and cluster stems as part of the wine.
- Eat To Beat Cancer: A Research Scientist Explains How You and Your Family Can Avoid Up to 90% of All Cancers by J. Robert Hatherill


Creasy's analysis of 30 types of wine found the most resveratrol in a red French Bordeaux and the least in a white Bordeaux.Dr. Creasy also found the anticoagulant in purple (but not white) grape juice. It takes about three times as much grape juice as red Bordeaux wine to get equal amounts of the compound, he figures. Table grapes, found in supermarkets, probably contain little of the substance because they are carefully cultivated to prevent fungal infections and blemishe